The Best American-Made Cars of All Time. "Made in America" is important, especially when it comes to auto manufacturing. At one time in America's history, Detroit was the undisputed center of the auto industry, with company headquarters and assembly centers.During the 1960s, for instance, Ford and General Motors went head-to-head in a race to provide the best muscle car. This time frame gave consumers such classics as the Camaro, the Mustang, the Challenger, and the Corvette. In the 1980s, Chrysler came out with the minivan design and, in the process, defined the image of the modern soccer mom. In 1948, Ford released the first true generation of its F-series. No longer was the truck based on a car's platform; it had its own fully truck-designed chassis. Who knew then that it would become the best-selling vehicle in America for 32 years straight. Even as we enter a new era of automotive history with electric vehicles, American designs are leading the way thanks to Tesla's Model S and Model 3 and Chevy's Volt and Bolt!These days, things are much more spread out (across the country and the globe). There are particular American-made cars that left an indelible mark upon the auto industry, however. Whether it was their groundbreaking design, unique features, or powerful capabilities, these American cars embodied the uniquely American feel of driving along long stretches of open highways.